反应详情

A mixture of 7-(2-ethyl-1-piperidinyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one (200 mg, 0.77 mmol) and phosphorus oxychloride (3.55 g, 23.1 mol) was refluxed for 12 h with stirring and concentrated to dryness under vacuum. The residue was purified by column chromatography eluting with a 10% acetone/hexanes mixture to afford 192 mg (90%) of the title compound.

1. temperaturewas refluxed for 12 h
2. concentrationconcentrated to dryness under vacuum
3. customThe residue was purified by column chromatography
4. washeluting with a 10% acetone/hexanes mixture