反应详情

温度

110 °C

A mixture of 2-chloro-7-(2-ethyl-1-piperidinyl)-1-methyl-1H-benzimidazole (100 mg, 0.36 mmol) and 4-bromo-2-methoxy-6-methylaniline (390 mg, 1.8 mmol) was heated at 110° C. for 12 h. The mixture was dissolved in ethyl acetate and washed with saturated sodium bicarbonate in water, dried over magnesium sulfate and concentrated under vacuum. The residue was purified by column chromatography eluting with a 15% acetone/hexanes mixture to afford 49.3 mg (30%) of the title compound.

1. washwashed with saturated sodium bicarbonate in water
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated under vacuum
4. customThe residue was purified by column chromatography
5. washeluting with a 15% acetone/hexanes mixture