3-methyl-4-nitro-1H-imidazo[4,5-c]pyridin-2(3H)-one → 4-Amino-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one

Participants

Reaction Steps

To a nitrogen inerted slurry of 2.24 g (11.5 mmol) of 3-methyl-4-nitro-1,3-dihydroimidazo[4,5-c]pyridin-2-one in 25 mL of methanol was added 0.5 mL of Raney nickel (50% slurry in water). The reaction slurry was purged with hydrogen and then stirred under balloon pressure hydrogen for 1 h. To the reaction slurry was added 20 mL of methanol and the reaction slurry was purged with hydrogen and then stirred under balloon pressure hydrogen for 2 h.

Provenance & Evidence