反应详情

To a slurry of 6.6 g of aluminum chloride and 20 ml of 1,3-difluorobenzene was added, with stirring at ambient temperature, 5.0 g of N-acetylisonipecotyl chloride. The reaction mixture was heated under reflux for 11/2 hrs and then poured onto 100 ml of ice and water. The mixture was extracted with chloroform. The chloroform fractions were combined, washed with water and dried over anhydrous magnesium sulfate and filtered. Evaporation of the filtrate gave an oil. Trituration of the oil with pentane gave 4.65 g (65.9%) of product, mp, 100°-102°.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 11/2 hrs
3. extractionThe mixture was extracted with chloroform
4. washwashed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customEvaporation of the filtrate
8. customgave an oil