Hydrochloric Acid → HCID 67067248, compound

HRID 2235783Notes

Reaction equation

HRID 2235783 reaction equation
[OH-].[Na+].[Cl:3][CH2:4][CH2:5][CH2:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=1)[C:8]([O:10]C)=[O:9].Cl>CO>[Cl:3][CH2:4][CH2:5][CH2:6][CH:7]([C:12]1[CH:13]=[CH:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=1)[C:8]([OH:10])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67067427HCID 67067427, compound

Product 1

HCID 67067248HCID 67067248, compoundYield 191.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 5 N sodium hydroxide solution (0.5 mL) was added to a solution of methyl 5-chloro-2-(4-dimethylaminophenyl)pentanoate (175 mg) in methanol (2 mL), and the reaction solution was stirred at room temperature for 23.5 hours. Thereafter, 1 N aqueous hydrochloric acid (2.5 mL) was added to the reaction solution, and the reaction solution was concentrated under reduced pressure to obtain 317 mg of the title compound. The property value of the compound is as follows.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fbe9878a8f1042dd8370a8628c0078ab
Source dataset
uspto-grants-2010_05
Patent number
US07713993B2

Reaction notes

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