Methane → HCID 178422887, compound

HRID 223591Notes

Reaction equation

HRID 223591 reaction equation
[C:1]([C:5]1[N:10]=[N:9][C:8]2[C:11]3[CH:17]=[CH:16][C:15]([CH3:18])=[N:14][C:12]=3[S:13][C:7]=2[C:6]=1[OH:19])([O:3]C)=[O:2].C>[OH-].[Na+].O>[C:1]([C:5]1[N:10]=[N:9][C:8]2[C:11]3[CH:17]=[CH:16][C:15]([CH3:18])=[N:14][C:12]=3[S:13][C:7]=2[C:6]=1[OH:19])([OH:3])=[O:2]

Participants

5

Reactant 2

HCID 297MethaneHCID 178499160HCID 178499160, compound

Product 1

HCID 178422887HCID 178422887, compoundYield 53%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4 g (0.015 mol) of 3-carbomethoxy-4-hydroxy-7-methylpyrido[3',2':4,5]thieno[3,2-C]pyridazine in 60 ml of 3% NaOH solution was stirred at room temperature for 2 hours. It was then diluted with water, treated with charcoal and filtered. It was acidified with acetic acid and filtered. Crystallization of the crude product from 3% NaOH/HOAC gave 2 g (53%) of 3-carboxy-4-hydroxy-7-methylpyrido[3',2':4,5]thieno[3,2-C]pyridazine, m.p.>300° C.

Workup

  1. filtrationfiltered
  2. filtrationfiltered
  3. customCrystallization of the crude product from 3% NaOH/HOAC

Sources & evidence

ORD record
ord-87aeb210ad7249048d464b807fb14a3e
Source dataset
uspto-grants-1982_10
Patent number
US04355164

Reaction notes

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