HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Diflunisal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylate | HCID 491921 | — |
| Product | Diflunisal | HCID 3059 | 98% |
Reaction Steps
The product of Step A. above is suspended in 80 ml. of aqueous sodium hydroxide (5%) and refluxed for 30 minutes. The mixture is acidified with aqueous hydrochloric acid and extracted three times with 150 ml. of toluene. The combined toluene extracts are concentrated and the 5-(2,4-difluorophenyl)salicylic acid is crystallized out. Filtration yields 29.4 mmole of final product, a 98% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04355174 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-be052fcb8a054b4d9d1508ec3c1b2e81 |
| Source note | uspto-grants-1982_10 |