反应详情

The product of Step A. above is suspended in 80 ml. of aqueous sodium hydroxide (5%) and refluxed for 30 minutes. The mixture is acidified with aqueous hydrochloric acid and extracted three times with 150 ml. of toluene. The combined toluene extracts are concentrated and the 5-(2,4-difluorophenyl)salicylic acid is crystallized out. Filtration yields 29.4 mmole of final product, a 98% yield.

1. extractionextracted three times with 150 ml
2. concentrationThe combined toluene extracts are concentrated
3. customthe 5-(2,4-difluorophenyl)salicylic acid is crystallized out
4. filtrationFiltration