Lithium Hydroxide → {[(1-Ethyl-1-methylpropoxy)carbonyl]amino}acetic acid

HRID 2236011Notes

Reaction equation

HRID 2236011 reaction equation
[CH2:1]([C:3]([CH3:16])([O:6][C:7]([NH:9][CH2:10][C:11]([O:13]CC)=[O:12])=[O:8])[CH2:4][CH3:5])[CH3:2].[OH-].[Li+]>CO.O>[CH2:1]([C:3]([CH3:16])([O:6][C:7]([NH:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86211537HCID 86211537, compound

Product 1

HCID 85792234{[(1-Ethyl-1-methylpropoxy)carbonyl]amino}acetic acid

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

300 mg (1.30 mmol) of ethyl {[(1-ethyl-1-methylpropoxy)carbonyl]-amino}acetate was dissolved in 2.5 ml of a solvent mixture of methanol:water (2.3:1). 1.56 ml of 1 N aqueous lithium hydroxide solution was added to the obtained solution. After stirring at room temperature for 2 hours, “DOWEX” (50W-X2 100 to 200 mesh H form) (an exchange resin of The Dow Chemical Company) was added to the reaction mixture under gentle stirring until pH of the mixture had become 5. The resin was obtained by the filtration under suction and then the filtrate was concentrated under reduced pressure and then dried to obtain the title compound.

Workup

  1. additionwas added to the reaction mixture
  2. stirringunder gentle stirring until pH of the mixture
  3. customThe resin was obtained by the filtration under suction
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customdried

Sources & evidence

ORD record
ord-a539d314b61e4ee285a086d477bae251
Source dataset
uspto-grants-2010_05
Patent number
US07713957B2

Reaction notes

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