Hydrogen chloride-ethyl acetate → HCID 68421306, compound

HRID 2236033Notes

Reaction equation

HRID 2236033 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[C:16]3[CH2:21][CH2:20][N:19]([C:22](=[O:40])[C@@H:23]([NH:32]C(=O)OC(C)(C)C)[CH2:24][NH:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:18][CH2:17]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[ClH:41].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:41].[NH2:32][C@H:23]([C:22]([N:19]1[CH2:18][CH2:17][C:16](=[C:6]2[C:5]3[CH:4]=[CH:3][CH:2]=[CH:1][C:11]=3[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]2=3)[CH2:21][CH2:20]1)=[O:40])[CH2:24][NH:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86594134HCID 86594134, compound

Product 1

HCID 68421306HCID 68421306, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1.40 g (2.57 mmol) of the compound obtained in step 1 described above was dissolved in 12 ml of ethyl acetate. 10 ml of 4 N hydrochloric acid/ethyl acetate was added to the obtained solution under cooling with ice. The temperature was gradually elevated to room temperature. After stirring for 3.5 hours, the solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. temperatureunder cooling with ice
  2. customwas gradually elevated to room temperature
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d11bfc43564c4e2c9d298ae61d80851c
Source dataset
uspto-grants-2010_05
Patent number
US07713957B2

Reaction notes

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