HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 2-(3-Ethoxy-azetidin-1-yl)-5-nitro-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(5-Nitropyridin-2-yl)azetidin-3-ol | HCID 52937264 | — |
| Product | 2-(3-Ethoxy-azetidin-1-yl)-5-nitro-pyridine | HCID 59301281 | 55.5% |
Reaction Steps
1-(5-Nitro-pyridin-2-yl)-azetidin-3-ol (97.5 mg, 0.5 mmol) was treated with 60% NaH in oil (60 mg, 1.5 mmol) and ethyl iodide (400 uL, 5 mmol) as above to yield 62 mg of product following purification by flash chromatography. ES-MS calcd for C10H13N3O3 (m/e) 223.23, obsd 224.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714126B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-4eba1fe8fb694b08a23e0a493fdd2e48 |
| Source note | uspto-grants-2010_05 |