Methylamine → HCID 59301414, compound

HRID 2236218Notes

Reaction equation

[CH3:1][N:2]([CH2:27][C:28]([OH:30])=O)[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2[N:13]=[C:14]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:15][C:16]=2[C:17]([F:20])([F:19])[F:18])=[O:11])=[CH:5][N:4]=1.[CH3:31][NH2:32]>>[CH3:1][N:2]([CH2:27][C:28](=[O:30])[NH:32][CH3:31])[C:3]1[N:4]=[CH:5][C:6]([NH:9][C:10]([C:12]2[N:13]=[C:14]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[O:15][C:16]=2[C:17]([F:18])([F:20])[F:19])=[O:11])=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 59301334HCID 59301334, compound

Product 1

HCID 59301414HCID 59301414, compound

Procedure

With a procedure similar to example 1 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-(methyl-methylcarbamoylmethyl-amino)-pyridin-3-yl]-amide was prepared from (methyl-{5-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-pyridin-2-yl}-amino)-acetic acid and methyl amine. LCMS calcd for C20H18F3N5O3 (m/e) 433, obsd 434 (M+H).

Sources & evidence

ORD record: ord-c093e023826e4fcab8bd22439841d940
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07714126B2

Reaction notes

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