Hydrochloric Acid → HCID 67536469, compound

HRID 2236247Notes

Reaction equation

HRID 2236247 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COCC([N:24]1[CH:29]=[C:28]([NH2:30])[CH:27]=[CH:26][CH:25]1[NH2:31])C.[ClH:32]>CCOCC>[ClH:32].[CH3:9][O:8][CH2:7][CH:1]([NH:31][C:25]1[N:24]=[CH:29][C:28]([NH:30][C:12]([C:10]2[N:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:8][C:9]=2[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:27][CH:26]=1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 67535953HCID 67535953, compound

Product 1

HCID 67536469HCID 67536469, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

With a method similar to example 16 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid-[6-(2-methoxy-1-methyl-ethylamino)pyridin-3-yl]amide hydrogen chloride was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and N-(2-methoxy-1-methyl-ethyl)-2,5-diaminopyridine. The purified oily material from column chromatography was dissolved in ether and treated with gaseous hydrogen chloride in ether (3N) to give a white precipitate as a hydrochloride salt. LCMS calcd for the neutral form C20H19F3N4O3 m/e 420.39, obsd 421.02 (ES, M+H).

Sources & evidence

ORD record
ord-b2418fae663a4bdab3eff6ea24cb485f
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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