5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid → 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid {6-[methyl-(2,2,2-trifluoro-ethyl)-amino]-pyridin-3-yl}-amide

HRID 2236250Notes

Reaction equation

HRID 2236250 reaction equation
[CH3:1][C:2]1[C:3]([C:13]([OH:15])=O)=[N:4][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH3:16][N:17]([CH2:25][C:26]([F:29])([F:28])[F:27])[C:18]1[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][N:19]=1>>[CH3:16][N:17]([CH2:25][C:26]([F:29])([F:27])[F:28])[C:18]1[N:19]=[CH:20][C:21]([NH:24][C:13]([C:3]2[C:2]([CH3:1])=[N:6][N:5]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:4]=2)=[O:15])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 5199365-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acidHCID 593013052,5-Pyridinediamine, N2-methyl-N2-(2,2,2-trifluoroethyl)-

Product 1

HCID 593014275-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid {6-[methyl-(2,2,2-trifluoro-ethyl)-amino]-pyridin-3-yl}-amide

Procedure

With a procedure similar to example 16 above, 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid {6-[methyl-(2,2,2-trifluoro-ethyl)-amino]-pyridin-3-yl}-amide was prepared from 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid and N2-methyl-N2-(2,2,2-trifluoro-ethyl)-pyridine-2,5-diamine. LCMS calcd for C18H17F3N6O (m/e) 390, obsd 391 (M+H). The NMR spectrum obtained on the sample is compatible with its structure.

Workup

  1. customThe NMR spectrum obtained on the sample

Sources & evidence

ORD record
ord-a75d91733996439396ae63b2aa6025d9
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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