1-Phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid → 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

HRID 2236256Notes

Reaction equation

HRID 2236256 reaction equation
[C:1]1([N:7]2[CH:11]=[C:10]([C:12]([OH:14])=O)[C:9]([C:15]([F:18])([F:17])[F:16])=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][CH2:21][CH2:22][N:23]([CH3:31])[C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][N:25]=1>>[CH3:19][O:20][CH2:21][CH2:22][N:23]([CH3:31])[C:24]1[N:25]=[CH:26][C:27]([NH:30][C:12]([C:10]2[C:9]([C:15]([F:18])([F:17])[F:16])=[N:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:11]=2)=[O:14])=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 149682451-Phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acidHCID 52937159N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamine

Product 1

HCID 593013631-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

Procedure

With a procedure similar to example 16 above, 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid and N2-(2-methoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C20H20F3N5O2 (m/e) 419, obsd 420 (M+H). The NMR spectrum obtained on the sample is compatible with its structure.

Workup

  1. customThe NMR spectrum obtained on the sample

Sources & evidence

ORD record
ord-f6ae86c971624c30aa6302378f5fa453
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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