N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamine → 2-(2-Chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

HRID 2236258Notes

Reaction equation

HRID 2236258 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]([C:16]([F:19])([F:18])[F:17])=[C:11]([C:13]([OH:15])=O)[N:12]=1.[CH3:20][O:21][CH2:22][CH2:23][N:24]([CH3:32])[C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][N:26]=1>>[CH3:20][O:21][CH2:22][CH2:23][N:24]([CH3:32])[C:25]1[N:26]=[CH:27][C:28]([NH:31][C:13]([C:11]2[N:12]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[O:9][C:10]=2[C:16]([F:19])([F:18])[F:17])=[O:15])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 52937159N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamineHCID 593014162-(2-Chlorophenyl)-5-trifluoromethyloxazole-4-carboxylic acid

Product 1

HCID 593014032-(2-Chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

Procedure

With a procedure similar to example 16 above, 2-(2-chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-(2-chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid and N2-(2-methoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C20H18ClF3N4O3 (m/e) 454, obsd 455 (M+H).

Sources & evidence

ORD record
ord-31f9ef7f195a4ecfb4253e70c65eb84f
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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