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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2236258Generated: October 31, 2026

N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamine → 2-(2-Chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

https://huagongshe.com/reaction/2236258

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamineHCID 52937159—
Reactant2-(2-Chlorophenyl)-5-trifluoromethyloxazole-4-carboxylic acidHCID 59301416—
Product2-(2-Chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amideHCID 59301403—

Reaction Steps

With a procedure similar to example 16 above, 2-(2-chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-(2-chloro-phenyl)-5-trifluoromethyl-oxazole-4-carboxylic acid and N2-(2-methoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C20H18ClF3N4O3 (m/e) 454, obsd 455 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07714126B2
Source datasetuspto-grants-2010_05
ORD IDord-31f9ef7f195a4ecfb4253e70c65eb84f
Source noteuspto-grants-2010_05