N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamine → 2-(2-Methoxy-phenyl)-4-trifluoromethyl-oxazole-5-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

HRID 2236307Notes

Reaction equation

HRID 2236307 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]([C:18]([OH:20])=O)=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=1.[CH3:21][O:22][CH2:23][CH2:24][N:25]([CH3:33])[C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][N:27]=1>>[CH3:21][O:22][CH2:23][CH2:24][N:25]([CH3:33])[C:26]1[N:27]=[CH:28][C:29]([NH:32][C:18]([C:11]2[O:10][C:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])=[N:13][C:12]=2[C:14]([F:15])([F:16])[F:17])=[O:20])=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 52937159N2-(2-methoxyethyl)-N2-methylpyridine-2,5-diamineHCID 593012902-(2-Methoxy-phenyl)-4-trifluoromethyl-oxazole-5-carboxylic acid

Product 1

HCID 593013302-(2-Methoxy-phenyl)-4-trifluoromethyl-oxazole-5-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide

Procedure

With a procedure similar to example 1 above, 2-(2-methoxy-phenyl)-4-trifluoromethyl-oxazole-5-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-(2-methoxy-phenyl)-4-trifluoromethyl-oxazole-5-carboxylic acid and N2-(2-methoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C21H21F3N4O4 (m/e) 450, obsd 451 (M+H).

Sources & evidence

ORD record
ord-adfbd45d9f094c868d507ef5ec08f84e
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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