2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301457, compound

HRID 2236313Notes

Reaction equation

HRID 2236313 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH3:15])[C:6]1[CH:7]=[N:8][C:9]([N+:12]([O-])=O)=[CH:10][CH:11]=1.[C:16]1([C:22]2[O:23][C:24]([C:30]([F:33])([F:32])[F:31])=[C:25]([C:27](O)=[O:28])[N:26]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH3:15])[C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:27]([C:25]2[N:26]=[C:22]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[O:23][C:24]=2[C:30]([F:32])([F:33])[F:31])=[O:28])=[N:8][CH:7]=1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 59301328HCID 59301328, compound

Product 1

HCID 59301457HCID 59301457, compound

Procedure

With a procedure similar to example 66 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {5-[(2-methoxy-ethyl)-methyl-amino]-pyridin-2-yl}amide was prepared from (2-methoxyethyl)-methyl-(6-nitropyridin-3-yl)-amine and 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid. The product was isolated as a yellow solid (200 mg, 37% yield). HRMS m/z calcd for C20H19F3N4O3 [M+H]+: 421.1482; Found: 421.1481.

Sources & evidence

ORD record
ord-029b4cf8f928488d98f35f87a3ede356
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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