1,2-Dimethylpropylamine, (S)- → N-((1S)-1,2-dimethylpropyl)-3-fluoro-5-methoxy-4-(2-propynyloxy)benzamide
Reaction equation
[CH3:1][C@H:2]([NH2:6])[CH:3]([CH3:5])[CH3:4].[F:7][C:8]1[CH:9]=[C:10]([CH:14]=[C:15]([O:21][CH3:22])[C:16]=1[O:17][CH2:18][C:19]#[CH:20])[C:11](Cl)=[O:12]>>[CH3:1][C@H:2]([NH:6][C:11](=[O:12])[C:10]1[CH:14]=[C:15]([O:21][CH3:22])[C:16]([O:17][CH2:18][C:19]#[CH:20])=[C:8]([F:7])[CH:9]=1)[CH:3]([CH3:5])[CH3:4]Participants
3
Procedure
According to the same method as that of Production Example 1, (1S)-1,2-dimethylpropylamine was used in place of 2,2-dimethylpropylamine, 3-fluoro-5-methoxy-4-(2-propynyloxy)benzoyl chloride was used in place of 4-(2-propynyloxy)-3-methoxybenzoyl chloride to obtain N-((1S)-1,2-dimethylpropyl)-3-fluoro-5-methoxy-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 49 of the present invention) represented by the formula:
Sources & evidence
- ORD record
- ord-eac582a4895b4f0b8a99c20a494ee928
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07714168B2
Reaction notes
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