反应详情

3-Hydroxy-benzonitrile (15 g, 0.126 mol) and iodine monochloride (28 g, 0.172 mol) is heated in acetic acid for 15 hours at 45° C. H2O is added to precipitate the product out. After the precipitate is collected and washed with Na2SO3, the residue is chromatographed with chloroform to get the product (2 g, 7%). MS (ESI): 244.0 (M−1)−1.

1. customto precipitate the product out
2. customAfter the precipitate is collected
3. washwashed with Na2SO3
4. customthe residue is chromatographed with chloroform