HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Hydroxy-2-iodobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Cyanophenol | HCID 13394 | — |
| Reactant | Iodine chloride | HCID 24640 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Hydroxy-2-iodobenzonitrile | HCID 68696052 | 7% |
Reaction Steps
3-Hydroxy-benzonitrile (15 g, 0.126 mol) and iodine monochloride (28 g, 0.172 mol) is heated in acetic acid for 15 hours at 45° C. H2O is added to precipitate the product out. After the precipitate is collected and washed with Na2SO3, the residue is chromatographed with chloroform to get the product (2 g, 7%). MS (ESI): 244.0 (M−1)−1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-9b9b4aeb07e34314be368335e162467d |
| Source note | uspto-grants-2010_05 |