Hydrazine → HCID 178493749, compound

HRID 2236460Notes

Reaction equation

HRID 2236460 reaction equation
[OH:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][N:5]=[C:4]([CH2:10][N:11]2C(=O)C3C(=CC=CC=3)C2=O)[N:3]=1.NN>CCO>[NH2:11][CH2:10][C:4]1[N:3]=[C:2]([OH:1])[C:7]([O:8][CH3:9])=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 178493744HCID 178493744, compound

Product 1

HCID 178493749HCID 178493749, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 2-(4-Hydroxy-5-methoxy-pyrimidin-2-ylmethyl)-isoindole-1,3-dione (50 mg, 0.18 mmol) is suspended in EtOH (2 mL) and to which NH2NH2 (0.5 mL) is added and the mixture is stirred till no starting material left. The precipitate is filtered and the filtrate is concentrated to provide the desired product, which is used directly without further treatment. MS (ESI): 156 (M+1)+1.

Workup

  1. additionis added
  2. waitleft
  3. filtrationThe precipitate is filtered
  4. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-b472194e393645b5a097f2e199102751
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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