HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2236461Generated: November 1, 2026
Thionyl Chloride → 4-Chloromethyl-2-methoxy-biphenyl
https://huagongshe.com/reaction/2236461
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Methoxy-biphenyl-4-yl)-methanol | HCID 22997534 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloromethyl-2-methoxy-biphenyl | HCID 59300124 | — |
Reaction Steps
(2-Methoxy-biphenyl-4-yl)-methanol (170 mg, 0.79 mmol) [PCT Int. Appl. 1999, WO 9955726 A1 19991104] is dissolved in CH2Cl2 (2 mL) and cooled to 0° C. SOCl2 (1 mL) is then added dropwise. The mixture is then allowed to stir till no starting material left. The volatiles were then removed and the crude product is employed in the next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07713994B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-10d5fa22698049f589b3170cda6d21d4 |
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| Source note | uspto-grants-2010_05 |
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