Aluminium lithium hydride → (4'-Fluoro-2-methoxy-biphenyl-4-yl)-methanol

HRID 2236467Notes

Reaction equation

HRID 2236467 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:7]([O:18][CH3:19])[CH:6]=1)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[F:17][C:14]1[CH:13]=[CH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([CH2:3][OH:2])=[CH:6][C:7]=2[O:18][CH3:19])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 592999004'-Fluoro-2-methoxy-biphenyl-4-carboxylic acid methyl ester

Product 1

HCID 59300176(4'-Fluoro-2-methoxy-biphenyl-4-yl)-methanol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4′-Fluoro-2-methoxy-biphenyl-4-carboxylic acid methyl ester (220 mg, 0.85 mmol) is allowed to dissolve in ether and cooled. LiAlH4 (80 mg, 2.12 mmol) is then added and the suspension is then stirred overnight. After aqueous work up, the alcohol is isolated and used directly in the next step.

Workup

  1. temperaturecooled

Sources & evidence

ORD record
ord-70584e60d60644e79344b038ccb41efa
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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