HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → (4'-Fluoro-2-methoxy-biphenyl-4-yl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 4'-Fluoro-2-methoxy-biphenyl-4-carboxylic acid methyl ester | HCID 59299900 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (4'-Fluoro-2-methoxy-biphenyl-4-yl)-methanol | HCID 59300176 | — |
Reaction Steps
4′-Fluoro-2-methoxy-biphenyl-4-carboxylic acid methyl ester (220 mg, 0.85 mmol) is allowed to dissolve in ether and cooled. LiAlH4 (80 mg, 2.12 mmol) is then added and the suspension is then stirred overnight. After aqueous work up, the alcohol is isolated and used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-70584e60d60644e79344b038ccb41efa |
| Source note | uspto-grants-2010_05 |