Boron tribromide → HCID 59300378, compound

HRID 2236486Notes

Reaction equation

HRID 2236486 reaction equation
[Br:1][C:2]1[C:9]([O:10]C)=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([F:12])[CH:3]=1.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[C:9]([OH:10])=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([F:12])[CH:3]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 575272884-broMo-2-fluoro-5-Methoxy-benzaldehyde

Product 1

HCID 59300378HCID 59300378, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-78 °C

Procedure

4-Bromo-2-fluoro-5-methoxy-benzaldehyde (100 mg, 0.43 mmol) is dissolved in CH2Cl2 and cooled to −78° C. and then BBr3 (2 mL, 1 M solution in CH2Cl2, 2 mmol) is added. The resulting mixture is allowed to stir at room temperature until no starting material is left. The reaction is quenched and the product is isolated after chromatography (60 mg, 57%). MS (ESI): 216.9 (M−1)−1.

Workup

  1. waitis left
  2. customThe reaction is quenched
  3. customthe product is isolated after chromatography (60 mg, 57%)

Sources & evidence

ORD record
ord-b17f48562cb442448910c7423e45e13c
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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