HuagongsheHuagongshe Chemistry Print Report · For research reference only
[1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine → 4-(2-Dimethylaminomethyl-pyrrolidin-1-yl)-3-fluoro-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine | HCID 59300313 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2-Dimethylaminomethyl-pyrrolidin-1-yl)-3-fluoro-phenylamine | HCID 59299834 | — |
Reaction Steps
[1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine (77 mg, 0.29 mmol) and Pd/C (16 mg, 10% weight) is shaken under H2 (50 psi) in MeOH overnight. After filtrating the Pd/C, the MeOH is removed and the residue obtained (65 mg, 95%) is directly employed in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-72326215d24742ad93850770abb4208c |
| Source note | uspto-grants-2010_05 |