Tert-butyl 2-(4-aminophenyl)pyrrolidine-1-carboxylate → 4-(1-Allyl-pyrrolidin-2-yl)-phenylamine

HRID 2236514Notes

Reaction equation

HRID 2236514 reaction equation
C(O[C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1)=O)(C)(C)C.[CH2:20](N1CCCC1C1C=CC(Br)=CC=1)[CH:21]=C>>[CH2:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[CH:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=1)[CH:20]=[CH2:21]

Participants

3

Reactant 2

HCID 44607625Tert-butyl 2-(4-aminophenyl)pyrrolidine-1-carboxylateHCID 513585141-Allyl-2-(4-bromo-phenyl)-pyrrolidine

Product 1

HCID 593002364-(1-Allyl-pyrrolidin-2-yl)-phenylamineYield 87%

Procedure

Using the same procedure described for the preparation of 2-(4-Amino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester, the title compound is prepared from 1-Allyl-2-(4-bromo-phenyl)-pyrrolidine (470 mg, 1.77 mmol) in 87% yield.

Sources & evidence

ORD record
ord-eb038161912042d88aa2d57b7d60aaf5
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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