HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Nitrobenzyl bromide | HCID 66011 | — |
| Reactant | Thiomorpholine 1,1-dioxide hydrochloride | HCID 12324096 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide | HCID 22569762 | — |
Reaction Steps
To a flask containing thiomorpholine 1,1-dioxide hydrochloride (0.65 g, 3.8 mmol) in CH3CN is added 4-nitrobenzylbromide (1.1 g, 5.1 mmol) and K2CO3 (1.9 g, 13.7 mmol). The mixture is then allowed to stir at room temperature overnight. After aqueous work up, the product is obtained through chromatography. MS (ESI): 271.1 (M+1)+1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-2996298731864d69928aee94ca189558 |
| Source note | uspto-grants-2010_05 |