4-Nitroaniline → HCID 16753198, compound

HRID 2236522Notes

Reaction equation

HRID 2236522 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11](=[O:13])[NH2:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+:14]([C:17]1[CH:23]=[CH:22][C:20](N)=[CH:19][CH:18]=1)([O-:16])=[O:15].ClC(OC1C=CC([N+]([O-])=O)=CC=1)=O>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11](=[O:13])[NH:12][C:20]2[CH:22]=[CH:23][C:17]([N+:14]([O-:16])=[O:15])=[CH:18][CH:19]=2)=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 74754-NitroanilineHCID 821294-Nitrophenyl chloroformateHCID 1699564-Nitrophenyl hydrogen carbonimidate

Product 1

HCID 16753198HCID 16753198, compound

Procedure

Using the procedure described for the preparation of 4-{[4(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-1,3-dioxo-1,2,3,4-tetrahyro-isoquinolin-6-yl)-carbamic acid 4-nitro-phenyl ester 5 g (26.0 mmol) of para-nitroanilin and 4-nitrophenyl chloroformate 14.6 g (72.4 mmol) were reacted to give (4-nitro-phenyl)-carbamic acid 4-nitro-phenyl ester, 11.0 g (100% yield) of yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-af8de45ae97a48dea9f1f47b91a6b489
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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