反应详情

2-Carboxymethyl-4-bromo-5-methoxy-benzoic acid (228 mg, 0.785 mmole) and urea (0.110 g, 1.82 mmole) is stirred and heated using an oil bath at 195° C. After one hour the mixture is cooled to room temperature and treated with water, collected by filtration, washed with water and dried to give a brown-black solid, 106 mg, (50%); MS (ES−): m/z 268.1, 270.1 (M−H).

1. temperatureheated
2. customat 195° C
3. filtrationcollected by filtration
4. washwashed with water
5. customdried
6. customto give a brown-black solid, 106 mg, (50%)