反应详情

To a suspension of sodium azide (2.82 g, 43.3 mmole) in 30 mL of N,N-dimethylformamide is added 2-chloromethyl-5-propoxy-pyridin-4-ol (8.74 g, 43.3 mmole). This is stirred for overnight at ambient temperature then quenched into ice water. The solid formed is filtered, washed with cold water and dried to give an off white solid, 5.74 g, (63%); MS (ES+): m/z 209.3 (M+H).

1. customthen quenched into ice water
2. customThe solid formed
3. filtrationis filtered
4. washwashed with cold water
5. customdried
6. customto give an off white solid, 5.74 g, (63%)