反应详情

2-Carboxymethyl-4-methoxy-benzoic acid (946 mg, 4.5 mmole) and urea (629 mg, 10.4 mmole) is stirred and heated using an oil bath at 180° C. After one hour the mixture is cooled to room temperature and treated with water, collected by filtration, washed with water and dried to give a brown solid, 498 mg, (57%); mp 212-5° C., MS (ESI): m/z 192.1 (M+H).

1. temperatureheated
2. customat 180° C
3. filtrationcollected by filtration
4. washwashed with water
5. customdried
6. customto give a brown solid, 498 mg, (57%)