Urea → HCID 59299941, compound

HRID 2236543Notes

Reaction equation

HRID 2236543 reaction equation
[C:1]([CH2:4][C:5]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:6]=1[C:7](O)=[O:8])(O)=[O:2].[NH2:16]C(N)=O>O>[CH3:15][O:14][C:12]1[CH:13]=[C:5]2[C:6](=[CH:10][CH:11]=1)[C:7](=[O:8])[NH:16][C:1](=[O:2])[CH2:4]2

Participants

4

Reactant 2

HCID 1176UreaHCID 118166262-(Carboxymethyl)-4-methoxybenzoic acid

Product 1

HCID 59299941HCID 59299941, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Carboxymethyl-4-methoxy-benzoic acid (946 mg, 4.5 mmole) and urea (629 mg, 10.4 mmole) is stirred and heated using an oil bath at 180° C. After one hour the mixture is cooled to room temperature and treated with water, collected by filtration, washed with water and dried to give a brown solid, 498 mg, (57%); mp 212-5° C., MS (ESI): m/z 192.1 (M+H).

Workup

  1. temperatureheated
  2. customat 180° C
  3. filtrationcollected by filtration
  4. washwashed with water
  5. customdried
  6. customto give a brown solid, 498 mg, (57%)

Sources & evidence

ORD record
ord-7451abf0ab6745b9b341d647fa3738a7
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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