HRID2236582

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID737253

4-(4-Methylpiperazino)aniline

C11H17N3

HCID68694591

(4E)-4-[(Dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone

C12H14N2O

PRODUCTS

生成物

$结构：CN1CCN(c2ccc(N/C=C3\C(=O)NCc4ccccc43)cc2)CC1$

HCID46183390

未命名化合物

收率 25.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度: 110 °C

PROCEDURE

实验过程

A toluene (3 mL) solution containing (4E)-4-[(dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone (300 mg, 1.48 mmol) and 4-(4-methyl-piperazin-1-yl) -phenylamine (318 mg, 1.66 mmol) is heated at 110° C. for 4 h. Using the same workup as example 1, 0.13 g (25%) orange solid is obtained: mp 186-187° C. (dec.); HRMS (ESI) m/z calcd for C21H24N4O 349.20229. found 349.20180 (M+H)+1.