HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2236582Generated: October 27, 2026
4-(4-Methylpiperazin-1-yl)aniline → (4Z)-4-({[4-(4-Methyl-1-piperazinyl)phenyl]amino}methylene)-1,4-dihydro-3(2H)-isoquinolinone
https://huagongshe.com/reaction/2236582
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(4-Methylpiperazin-1-yl)aniline | HCID 737253 | — |
| Reactant | (4E)-4-[(Dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone | HCID 68694591 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (4Z)-4-({[4-(4-Methyl-1-piperazinyl)phenyl]amino}methylene)-1,4-dihydro-3(2H)-isoquinolinone | HCID 46183390 | 25.2% |
Reaction Steps
A toluene (3 mL) solution containing (4E)-4-[(dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone (300 mg, 1.48 mmol) and 4-(4-methyl-piperazin-1-yl) -phenylamine (318 mg, 1.66 mmol) is heated at 110° C. for 4 h. Using the same workup as example 1, 0.13 g (25%) orange solid is obtained: mp 186-187° C. (dec.); HRMS (ESI) m/z calcd for C21H24N4O 349.20229. found 349.20180 (M+H)+1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07713994B2 |
|---|
| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-92a199a44b9b467e81d082e40a2cc0ba |
|---|
| Source note | uspto-grants-2010_05 |
|---|
