反应详情

温度

100 °C

A mixture of 4-methoxymethylene-6-pyrrol-1-yl-4H-isoquinoline-1,3-dione, (100 mg, 0.3727 mmol), 4-(4-methyl-piperazin-1-yl)-phenylamine (71.3 mg, 0.3727 mmol) in 1 mL of N,N-dimethylformamide is heated at 100° C. for 0.5 h. After the solvent is evaporated, ether is added to the residue. The precipitate is collected, and washed with ether to give 122 mg (77%) of light brown solid mp 239-240° C.; HRMS (ESI) m/z calcd for C25H25N5O2 428.20811. found 428.20865 (M+H)+1, Analysis for C25H25N5O2 (0.6H2O), Calcd: C, 68.51; H, 6.02; N, 15.98. Found: C, 68.67; H, 5.85; N, 15.62.

1. customAfter the solvent is evaporated
2. additionether is added to the residue
3. customThe precipitate is collected
4. washwashed with ether