反应详情

Using the procedure described for the preparation of example 46, 50 mg of orange solid (40% yield) is obtained from 80 mg (0.29 mmol) of 4-methoxymethylene-6-phenyl-3-yl-isoquinolin-(4H)-1,3-dione and 3-hydroxy-4,5-dimethoxybenzylamine 115 mg (0.29 mmol), (prepared similarly to (4E)-6,7-dimethoxy-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 3-hydroxy-4-methoxy-benzylamine hydrogen chloride, except methoxy amine hydrogen chloride is used instead of hydroxylamine hydrogen chloride); mp 250-251° C.