4-(2-Piperazin-1-yl-ethyl)-morpholine → HCID 59299873, compound

Participants

Reaction Steps

A mixture of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (200 mg, 0.709 mmol), 2-morpholinylethylpiperazine (141.3 mg, 0.709 mmol) in 1 mL of N,N-dimethylformamide is stirred at room temperature for 15 min. After cooling in the refrigerator, the precipitate is collected, and washed with N,N-dimethylformamide (DMF) and ether to give 64 mg (20%) of yellow solid mp 156-156.5° C.; HRMS (ESI) m/z 449 (M+H)+1.

Provenance & Evidence