4-(2-Piperazin-1-yl-ethyl)-morpholine → HCID 59299873, compound

HRID 2236616Notes

Reaction equation

HRID 2236616 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])[C:5]2=[CH:14]OC.[N:17]1([CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[N:28]1[CH2:27][CH2:26][N:25]([CH2:24][CH2:23][N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[CH2:30][CH2:29]1

Participants

4

Reactant 2

HCID 27346404-(2-Piperazin-1-yl-ethyl)-morpholineHCID 686927644-methoxymethylene-6-bromo-4H-isoquinoline-1,3-dione

Product 1

HCID 59299873HCID 59299873, compoundYield 20.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (200 mg, 0.709 mmol), 2-morpholinylethylpiperazine (141.3 mg, 0.709 mmol) in 1 mL of N,N-dimethylformamide is stirred at room temperature for 15 min. After cooling in the refrigerator, the precipitate is collected, and washed with N,N-dimethylformamide (DMF) and ether to give 64 mg (20%) of yellow solid mp 156-156.5° C.; HRMS (ESI) m/z 449 (M+H)+1.

Workup

  1. temperatureAfter cooling in the refrigerator
  2. customthe precipitate is collected
  3. washwashed with N,N-dimethylformamide (DMF) and ether

Sources & evidence

ORD record
ord-d97bea46001e4caa9fffa8cfc531fa5d
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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