反应详情

A solution of 0.400 g (1.98 mmol) of (4E)-4-[(Dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone and 0.300 g (1.58 mmol) of 4-piperidin-1-ylmethyl-phenylamine in 4 mL of N,N-dimethylformamide (DMF) is heated at 125° C. for 3 h. The solvent is removed and the residue is slurried with Et2O and filtered. The Et2O soluble material is evaporated, redissolved in a small volume of PhCH3 and chilled. A precipitate is collected, boiled with MeOH (ca 20 mL) and filtered. The filtrate is evaporated and the residue is recrystallized from a minimum volume of MeOH. The resulting solid is collected, washed with cold MeOH and Et2O and dried in vacuo to yield 0.087 g (13%) of yellow crystals: mp 188-189° C. (dec); 1H NMR (DMSO-d6) δ 11.5 (d, 1H, J=11.8 Hz), 8.04 (d, 1H, J=11.8 Hz), 7.66 (m, 2H), 7.20 (s, 5H), 7.08 (m, 2H), 4.41 (s, 2H), 3.34 (s, 2H), 2.29 (s(br), 4H), 1.46 (m, 6H); HRMS (ESI) m/e calcd for C22H25N3O 348.20704. found 348.20704 (M+H)+1.

1. customThe solvent is removed
2. filtrationfiltered
3. customThe Et2O soluble material is evaporated
4. dissolutionredissolved in a small volume of PhCH3
5. temperaturechilled
6. customA precipitate is collected
7. filtrationfiltered
8. customThe filtrate is evaporated
9. customthe residue is recrystallized from a minimum volume of MeOH
10. customThe resulting solid is collected
11. washwashed with cold MeOH and Et2O
12. customdried in vacuo