Hydrochloric Acid → 247570-27-0

HRID 2236657Notes

Reaction equation

HRID 2236657 reaction equation
CO[N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([F:13])[CH:6]=1.[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=1[O:11][CH3:12])[CH2:4][NH2:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 87542948HCID 87542948, compound

Product 1

HCID 22467403247570-27-0

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 3-fluoro-4-methoxy-benzaldehyde O-methyl-oxime (0.60 g, 3.3 mmol) in ethanol (25 mL) is added concentrated ethanolic hydrogen chloride (2 mL) and palladium on carbon (10%, 250 mg). The suspension is hydrogenated at atmospheric pressure for 18 hours, then filtered through diatomaceous earth and finally concentrated to give 3-fluoro-4-methoxy-benzylamine hydrochloride as a white solid.

Workup

  1. filtrationfiltered through diatomaceous earth
  2. concentrationfinally concentrated

Sources & evidence

ORD record
ord-4749d880f44b4308984218dbc2650049
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

Loading…