HCID 42625428, compound → HCID 22134352, compound

HRID 2236663Notes

Reaction equation

HRID 2236663 reaction equation
[N:1]([CH:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14]CC2C=CC=CC=2)[CH:7]=1)[CH3:5])=[N+]=[N-]>Cl.[Pd]>[NH2:1][CH:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([OH:14])[CH:7]=1)[CH3:5]

Participants

4

Reactant 1

HCID 42625428HCID 42625428, compound

Product 1

HCID 22134352HCID 22134352, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolvent

Procedure

Crude 4-(1-azido-ethyl)-2-benzyloxy-1-methoxybenzene is hydrogenated at 50 psi, using 10% Pd/C in ethanolic hydrogen chloride solution to give 5-(1-amino-ethyl)-2-methoxyphenol.

Sources & evidence

ORD record
ord-7f7609bfca8e40649e0c0a8ce4346db2
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

Loading…