反应详情

温度

110 °C

A mixture of (4E)-6-bromo-7-methoxy-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (156 mg, 0.50 mmole), N,N-dimethylformamide (1 mL) and 4-(4-Methyl-piperazin-1-yl)-phenylamine (96 mg, 0.50 mmole) is stirred and heated at 110° C. for one hour, cooled in the refrigerator. The reaction mixture is evaporated to dryness, taken up in 5% methanol in chlororform and passed through a short pad of Florisil eluting with 5% methanol in chloroform. The eluate is evaporated in vacuo and treated with acetonitrile, filtered and dried to give a brown solid 110 mg (47%), mp 274-276° C.; MS (ESI): m/z 471.1, 473.1 (M+H).

1. temperaturecooled in the refrigerator
2. customThe reaction mixture is evaporated to dryness
3. customThe eluate is evaporated in vacuo
4. additiontreated with acetonitrile
5. filtrationfiltered
6. customdried