2-(Methyl(4-nitrophenyl)amino)ethan-1-ol → 2-[(4-Aminophenyl)(methyl)amino]ethan-1-ol

HRID 2236709Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236709
[CH3:1][N:2]([CH2:12][CH2:13][OH:14])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][CH:4]=1>C(O)C.[Pd]>[NH2:9][C:6]1[CH:5]=[CH:4][C:3]([N:2]([CH3:1])[CH2:12][CH2:13][OH:14])=[CH:8][CH:7]=1

Komponenten

4

Edukt 1

HCID 45470772-(Methyl(4-nitrophenyl)amino)ethan-1-ol

Produkt 1

HCID 136283162-[(4-Aminophenyl)(methyl)amino]ethan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-(methyl-4-nitroanilino)ethanol (0.20 g, 1.0 mmol) in ethanol (25 mL) is hydrogenated for two hours at atmospheric pressure over 10% Pd/C. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to give 2-[(4-amino-phenyl)-methyl-amino]-ethanol as a dark oil, which solidified upon standing.

Aufarbeitung

  1. filtrationThe mixture is filtered through a pad of diatomaceous earth
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1921b43e86824929988beda0f84656af
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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