HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2236737Generated: October 29, 2026
Hydrochloric Acid → N-[3-(4-amino-phenyl)-propyl]-O-methyl-hydroxylamine dihydrochloride
https://huagongshe.com/reaction/2236737
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[4-(3-methoxyamino-propyl)-phenyl]-acetamide | HCID 86619588 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[3-(4-amino-phenyl)-propyl]-O-methyl-hydroxylamine dihydrochloride | HCID 86619589 | — |
Reaction Steps
A mixture of N-[4-(3-methoxyamino-propyl)-phenyl]-acetamide (0.50 mmol) and 20% aqueous hydrochloric acid (2 mL) in methanol (8 mL) is heated for 18 hours at 60° C. and then concentrated under reduced pressure to give N-[3-(4-amino-phenyl)-propyl]-O-methyl-hydroxylamine dihydrochloride (62 mg, 0.24 mmol) and is used in the following step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07713994B2 |
|---|
| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-ad2c55582a724c18a57e9cf613bbb046 |
|---|
| Source note | uspto-grants-2010_05 |
|---|
