反应详情

A mixture of 2-aminomethyl-5-hydroxy-pyran-4-one (106 mg, 0.75 mmole), 4 mL of N,N-dimethylformamide and 4-methoxymethylene-6-bromo-4H-isoquinoline-1,3-dione (212 mg, 0.75 mmole) is stirred for one hour at ambient temperature. The reaction mixture is evaporated to dryness, dissolved in 7.5% methanol in chloroform passed through Florisil eluting with 7.5% methanol in chloroform. The eluate is evaporated, treated with acetonitrile, the resulting solid filtered and dried to give an off white solid, 220 mg, (75%), mp 293-7° C. dec; MS (ES+): m/z 391 (M+H).

1. customThe reaction mixture is evaporated to dryness
2. dissolutiondissolved in 7.5% methanol in chloroform
3. customThe eluate is evaporated
4. additiontreated with acetonitrile
5. filtrationthe resulting solid filtered
6. customdried
7. customto give an off white solid, 220 mg, (75%), mp 293-7° C. dec