反应详情

A mixture of 2-aminomethyl-5-methoxy-pyran-4-one (116 mg, 0.75 mmole), 4 mL of N,N-dimethylformamide and 4-methoxymethylene-6-pyrrol-1-yl-4H-isoquinoline-1,3-dione (201 mg, 0.80 mmole) is stirred for one hour at ambient temperature. The reaction mixture is evaporated to dryness, dissolved in 7.5% methanol in chloroform passed through Florisil eluting with 7.5% methanol in chloroform. The eluate is evaporated, treated with acetonitrile, the resulting solid filtered and dried to give a beige solid, 106 mg, (36%), mp 251-4° C. dec; MS (ES−): m/z 390.1 (M−H).

1. customThe reaction mixture is evaporated to dryness
2. dissolutiondissolved in 7.5% methanol in chloroform
3. customThe eluate is evaporated
4. additiontreated with acetonitrile
5. filtrationthe resulting solid filtered
6. customdried
7. customto give a beige solid, 106 mg, (36%), mp 251-4° C. dec