HCID 178429948, compound → 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline

HRID 2236771Notes

Reaction equation

HRID 2236771 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:15]/C=C2\C(=O)NC(=O)C3C\2=CC(N2C=CC=C2)=CC=3)[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]1.BrC1C=C2C(=CC=1)C(=O)NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([NH2:15])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178480740HCID 178480740, compound

Product 1

HCID 27830553-Fluoro-4-(4-methylpiperazin-1-yl)aniline

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.28 g of tan solid is obtained from 0.2 g (0.746 mmol) of (4E)-4-(methoxy-8.42 g (methylene)-6-(1H-pyrrol-1-yl)isoquinoline-1,3(2H,4H)-dione and 0.187 g (0.895 mmol) of [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine: mp 206-207° C.; MS (ESI) m/z 446.2 (M+H)+1

Sources & evidence

ORD record
ord-fc97568c49be453998d104ae65132205
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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