HCID 178429948, compound → 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline

Participants

Reaction Steps

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.28 g of tan solid is obtained from 0.2 g (0.746 mmol) of (4E)-4-(methoxy-8.42 g (methylene)-6-(1H-pyrrol-1-yl)isoquinoline-1,3(2H,4H)-dione and 0.187 g (0.895 mmol) of [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine: mp 206-207° C.; MS (ESI) m/z 446.2 (M+H)+1

Provenance & Evidence